醫學研究部簡介  
活動訊息
各研究室介紹
部內各項公共儀器
定序與流式細胞服務
常用表單下載  
人體試驗相關訊息
相關醫學網站連結
各單位聯絡資訊
 
 
 

 

  

研究室介紹>一樓> 共研一

共同實驗室(一)

共同實驗室(一)由組長陳裕仁主持，

並由一群醫師、科學家、博士後研究員與研究助理組成研究團隊

主要研究方向為 :

開發抗癌藥物，樹突細胞疫苗以及癌症幹細胞標靶治療。

內容結合基礎科學及Translational 研究，並涵蓋藥理及前臨床研究模式，

並以促進癌症治療進展為職志
壹、 目前主要研究方向及進行中之研究計畫：

研究方向:


1. Develop new anti-cancer drugs and radiosensitizers

2. Immunobiology of dendritic cells and endothelial progenitor cells

3. Targeting cancer stem cells

 

進行中之研究計畫：

    1. 子宮頸癌接受同步放射化學治療對血中內皮前驅細胞之作用: 臨床試驗,動物模式及分子機轉研究(96-2321-B-195-001-MY2

    2. Cordycepin 誘導人類肝癌細胞死亡作用及機轉之探討

    3. 利用基因改造之樹突細胞建立治療肝癌之疫苗

    4. Platonin對樹突細胞分化, 成熟, 及皮膚移植之作用

    5. Costunolide 對於肝癌細胞毒殺作用及放射致敏之機轉研究
貳、實驗室主持人：陳裕仁 醫師

1. 主要學歷：

國立陽明大學傳統醫藥研究所博士

2. 經歷：

馬偕紀念醫院放射腫瘤科 住院醫師 總醫師 主治醫師

中國文化大學國術系 兼任講師 助理教授 副教授(教育部部定)

3. 現職：

馬偕紀念醫院放射腫瘤科主治醫師

國立陽明大學傳統醫藥研究所 兼任副教授

台北醫學大學藥學研究所 兼任副教
參、實驗室沿革：
 
肆、實驗室成員：

助研究員: 林景屏MS

研究助理: 許敏玲 謝慧如

專案研究助理 :

黃建穎

楊凱茜

許文怡

李俐慧

曾玉如MS

林桂滿MS
伍、近三年研究成果及發表之論文

SCI paper:

  1. Chen YJ, Sims-Mourtada J, Izzo JG, Clifford K.S. Chao. (2007) Targeting the Hedgehog pathway to mitigate treatment resistance. Cell Cycle (in press).
  2. Liao HF, Yang YC, Chen YY, Hsu ML, Shieh HR, Chen YJ*. (2007) Macrophages derived from bone marrow modulate differentiation of myeloid dendritic cells. Cell Mol Life Sci. 64(1):104-111. (SCI)
  3. Wu CJ, Sheu JR, Chen HH, Liao HF, Yang YC, Yang S, Chen YJ*. (2006)
    Renal ischemia/reperfusion injury inhibits differentiation of dendritic cells derived from bone marrow monocytes in rats. Life Sci. 78(10):1121-1128. (SCI) 國科會計畫編號: 91-2413-H-195-001.
  4. Wu CJ, Sheu JR, Chen HH, Liao HF, Yang YC, Yang S, Chen YJ*. (2006) Modulation of monocyte-derived dendritic cell differentiation is associated with acute ischemic renal failure. J. Surg.Res. 132(1):104-111. (SCI) 國科會計畫編號: 91-2413-H-195-001.
  5. Yang YC, Wang KL, Su TH, Liao HF, Wu MH, Chen TC, Huang MC, Chen YJ*. (2006) Concurrent Cisplatin-based Chemoradiation for Cervical Carcinoma: Tumor Response, Toxicity and Serum Cytokine Profiles. Cancer Investigation 24(4):390-395. (SCI)
  6. Lee JJ, Liao HF, Yang YC, Liu CL, Chen YY, Lin CP, Chen YJ*. (2006) Platonin modulates differentiation and maturation of human monocyte-derived dendritic cells. International Immunopharmacology 6(2):287-293. (SCI)
  7. Liao HF, Chen YY, Yang YC, Wang CS, Chen YJ*. (2006) Rice (Oryza sativa L.) inhibits growth and induces differentiation of human leukemic U937 cells through activation of peripheral blood mononuclear cells. Food Chem. Toxicol. 44: 1724-1729. (SCI)
  8. Liao HF, Chiang LM, Yen CC, Chen YY, Zhuang RR, Lai LY, Chiang J, Chen YJ*. (2006) Effect of a periodized exercise training and active recovery program on anti-tumor activity and development of dendritic cells. Journal of Sports Medicine and Physical Fitness 46(2):307-314. (SCI)
  9. Chiang LM, Chen YJ, Chiang J, Lai LY, Chen YY, Liao HF. (2006) Modulation of Dendritic Cells by Endurance Training. Int. J. Sports Med. (in press) (SCI)
  10. Hsieh CH, Chen YJ, Chang KH, Hsu HH, Liu CK, Hung SK, Chen HW, Lai YL, Hsu TC. (2006) Post-operative concurrent chemoradiation therapy using oral uracil-tegafur versus weekly intravenous fluorouracil for locally advanced rectal cancer. Anticancer Res. 26(5B):3709-3715.(SCI)
  11. Wang SL, Lin TY, Yen YH, Liao HF, Chen YJ. (2006) Bioconversion of shellfish chitin wastes for the production of Bacillus subtilis W-118 chitinase. Carbohydr Res. 341(15):2507-2515. (SCI)
  12. Chen YJ, Liao HF, Tsai TH, Wang SY, Shiao MS. (2005) Caffeic acid phenethyl acid preferentially sensitizes CT26 colorectal adenocarcinoma to ionizing radiation without affecting bone marrow radioresponse. Int. J. Rdiat. Oncol. Biol. Phys. 63(4):1252-1261.(SCI) 國科會計畫編號:91-2314-B-195-009.
  13. Chen YJ, Shieh CJ, Tsai TH, Kuo CD, Ho LT, Liu TY, Liao HF. (2005) Inhibitory effect of norcantharidin, a derivative compound from blister beetles, on tumor invasion and metastasis in CT26 colorectal adenocarcinoma cells. Anti-Cancer Drugs. 16(3): 293-299. (SCI)
  14. Liao HF, Shyu SY, Kuo YH, Yang YC, Chen YJ*. (2005) Compound 278E, structurally modified from tanshinone, induces monocytic differentiation and regulates proto-oncogenes expression in human leukemic HL-60 cells. Anti-Cancer Drugs. 16:175-183. (SCI) 國科會計畫編號:93-2314-B-195-001.
  15. Huang HL, Wu SL, Liao HF, Jiang CM, Huang RL, Chen YY, Yang YC, Chen YJ*. (2005) Induction of Apoptosis by Three Marine Algae through Generation of Reactive Oxygen Species in Human Leukemic Cell Lines. J. Agri. Food Chem. 53:1776-81. (SCI) 國科會計畫編號:91-2314-B-195-009.
  16. Chang KH, Liao HF, Chang HH, Chen YY, Yu MC, Chou CJ, Chen YJ*. (2004) Inhibitory effect of tetrandrine on pulmonary metastases in CT26 colorectal adenocarcinoma–bearing BALB/c mice. Am.J. Chin. Med. 32(6):863-872. (SCI). 國科會計畫編號: 92-2311-B-195-002.
  17. Liao HF, Kuo CD, Yang YC, Lin CP, Tai HC, Chen YY, Chen YJ*. (2005) Resveratrol Enhances Radiosensitivity of Human Non-Small Cell Lung Cancer NCI-H838 Cells Accompanied by Inhibition of Nuclear Factor-Kappa B Activation. J. Radiat. Res. 46: 387-393. (SCI)
  18. Ou HT, Shieh CJ, Chen YJ, Chang HM. (2005) The antiproliferative and differentiating effects of human leukemic U937 cells are mediated by cytokines from activated mononuclear cells by dietary mushrooms. J. Agri. Food Chem. 53:1776-81. (SCI)
  19. Leu YS, Hsiao HT, Chang YC, Yang CC, Lee JC, Chen YJ, Chang YF. (2005) Ileocolic free flap reconstruction, concomitant chemotherapy and radiotherapy and assessment of speech and swallowing function during management of advanced cancer of the larynx and hypopharynx: preliminary report. Acta Otolaryngol.. 125(6): 642-646. (SCI)
  20. Chen HW, Chang YC, Lai YL, Chen YJ, Huang MJ, Leu YS, Fu YK, Wang LW, Hwang JJ. (2005) Change of plasma transforming growth factor-beta1 levels in nasopharyngeal carcinoma patients treated with concurrent chemo-radiotherapy. JpnJClinOncol.,35(8):427-432..(SCI)
  21. Liao HF, Chen YJ, Yang YC. (2005) A novel polysaccharide of black soybean promotes myelopoiesis and reconstitutes bone marrow after 5-flurouracil- and irradiation-induced myelosuppression. Life Sci. 77:400-413. (SCI)
  22. Chen MF, Wu CT, Chen YJ, Keng PC, Chen WC. (2004) Cell killing and radiosensitization by caffeic acid phenethyl ester (CAPE) in lung cancer cells. J. Radiat. Res. 45(2):253-60. (SCI)
  23. Wu CJ, Sheu JR, Chen HH, Shyur SD, Chen PG, Chen YJ*. (2003) Anti-leukemic immunity against U937 cells in uremic patients. Neoplasma 50(1): 54-59. (SCI).
  24. Lai YL, Chang HH, Huang MJ, Chang KH, Su WH, Chen HW, Chung CH, Wang WY, Lin LH, Chen YJ*. (2003) Combined effect of topical arsenic trioxide and radiation therapy on skin infiltrating lesions of breast cancer –a pilot study. Anti-Cancer Drugs 14(10):825-828. (SCI)
  25. Liao HF, Chen YY, Liu JJ, Hsu ML, Shieh HJ, Liao HJ, Shieh CJ, Shiao MS, Chen YJ*. (2003) The Inhibitory Effect of Caffeic Acid Phenethyl Ester on Angiogenesis, Tumor Invasion and Metastasis. J.Agri. Food Chem. 51(27):7907-7912. (SCI) 國科會計畫編號: 91-2314-B-195-009.
  26. Chen YJ*. (2002) Potential role of tetrandrine in cancer therapy. [review] Acta Pharmacol. Sin.23(12): 1102-1106. (SCI).
  27. Liu HC, Hsu WH, Chen YJ, Chan YJ, Wu YC, Huang BS, Huang MH. (2002) Primary thymic carcinoma. Ann. Thorac. Sug. 73: 1076-1081. (SCI).
  28. Chen YJ, Shiao MS, Wang SY. (2001) The antioxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human eukemic HL-60 cells.Anti-cancer Drug. 12: 143-149. (SCI)
  29. Chung CC, Chiang J, Chiang CM, Chen YY, Huang CY, Chen PG, Chen YJ*. (2001) Basic fibroblast growth factor as a growth factor for SRV-2-infected simian retroperitoneal fibromatosis cells, an animal model for AIDS- related Kaposi’s sarcoma. Neoplasma 48(3): 192-199. (SCI)
  30. Chen YJ, Shiao MS, Hsu ML, Tsai TH, Wang SY. (2001) The Effect of Caffeic Acid Phenethyl Ester, an Antioxidant from Propolis, on Inducing Apoptosis in Human Leukemic HL-60 Cells. J. Agri. Food Chem. 49: 5615-5619. (SCI). 國科會計畫編號: 90-2314-B-195-024.
  31. Chiang J, Chen ML, Huang YW, Huang AG, Chen YJ*. (2000) Comparison of anti-leukemic immunity against U937 cells in endurance athletes versus sedentary controls. International Journal of Sports Medicine 21: 602-7. (SCI)
  32. Chen YJ, Dai YS, Chen BF, Chang A, Chen HC, Lin YC, Chang KH, Lai YL, Chung CH, Lai YJ. (1999) The effect of Tetrandrine and extracts of Centella asiatica on acute radiation dermatitis in rats.Biol. Pharm. Bull. 22 (7) 703-6. (SCI)
  33. Chen YJ, Shyur SD,Wang CY, Huang KY, Chao YK, Chen PG. (1999) Comparison of anti-leukemic immunity against U937 cells in atopic asthmatics and healthy controls. Neoplasma 46(5): 304-8.(SCI)
  34. Chen YJ, Lo KY, Tzen CY, Huang RD, Chang KH, Lai YL, Chen ML. (1999) Relationship of Bcl-2 and pp125FAK expression to outcome of radiation therapy in prostate carcinoma. J. Tumor Marker Oncol. 14(3): 19-23. (SCI)
  35. Chang KH, Chen ML, Chen HC, Huang YH, Wu TY, Chen YJ*. (1999) Enhancement of radiosensitivity in human glioblastoma U138MG cells by tetrandrine. Neoplasma 46(3):196-200.(SCI)
  36. Chen MF, Chen YJ, Lai YL, Shin BF, Chang KH, Chung CH. (1999) The prognostic significance of serum tumor marker in breast cancer. J. Tumor Marker Oncol. 14(1):19-25. (SCI)
  37. Lai YL, Chen YJ, Wu TY, Wang SY, Chang KH, Chung CH, Chen ML. (1998) Induction of apoptosis in human leukemic U937 cells by tetrandrine. Anti-Cancer Drugs 9(1): 77-81. (SCI)
  38. Chen YJ, Shiao MS, Lee SS, Wang SY. (1997) Effect of Cordyceps Sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Science 60(25): 2349-59. (SCI)
  39. Chen YJ, Tu ML, Kuo HC, Chang KH, Lai YL, Chung CH, Chen ML. (1997) Protective effect of tetrandrine on normal human mononuclear cells against ionizing irradiation. Biol. Pharm. Bull.20(11): 1160-64. (SCI)
陸、近五年所進行中研究計畫：
  1. 探討咖啡酸苯乙酯抑制血管新生、腫瘤侵犯及轉移之作用(91-2314-B-195-009- )
  2. 太極拳對人體樹突細胞分化及成熟之影響(93-2413-H-195-001- )
  3. 化合物278A及其化學衍生物對肺癌、食道癌及胰臟癌之放射致敏作用(94-2314-B-195-019-)
  4. 化合物278A對肺癌及胰臟癌之放射致敏作用(II) – 活體藥效、藥物動力學及機轉研究(95-2314-B-195-014-)
  5. 子宮頸癌接受同步放射化學治療對血中內皮前驅細胞之作用: 臨床試驗,動物模式及分子機轉研究 (96-2321-B-195-001-MY2)
  6. 利用基因改造之樹突細胞建立治療肝癌之疫苗MMH-E-95006
  7. Platonin對樹突細胞分化, 成熟, 及皮膚移植之作用 MMH-9647
  8. Cordycepin 誘導人類肝癌細胞死亡作用及機轉之探討 MMH-9674
  9. 人體內樹突細胞分化之研究 MMH-95108
  10. 子宮頸癌病患A點定位研究MMH-94120
  11. 中草藥抗發炎藥效篩檢模式之建立:以樟芝抗寄生蟲作用為例MMH-9578
柒、實驗室儀器介紹：
  1. 基本細胞培養及分生實驗所需之儀器皆具備
  2. 螢光/可見光全波長盤式分析儀
  3. 流式細胞儀 Flow cytometry
  4. Facs Array生物活性分析



 
   
 
Top