大數據研究組

負責醫師：洪崇烈 醫師

大數據之應用有利於科學研究發展，為學界所公認。在實證醫學、遠距醫療發展成為重要醫學研究內涵時，大數據也成為醫學研究的重要一環。馬偕醫院醫學研究部於2018年成立大數據研究組，短期目標以協助馬偕醫院所有對大數據研究有興趣之醫師、醫事、護理及行政同仁，提供研究設計的統計諮詢與資料分析的相關服務。長期目標期望整合臨床電子病歷資料庫、政府官方釋出之資料庫、癌登資料庫等，建立跨領域資料平台，發揮大數據價值，提升馬偕醫院醫療體系之學術地位，促進全民健康。

精神疾病及心理社會問題流行病學研究
自殺相關流行病學及治療研究
精神疾病患者的生理健康問題研究
身心介面及流行病學研究

精神疾病患者得心肌梗塞的危險性高於非精神疾病患者。

精神疾病患者得心肌梗塞之後受到的醫療照護，住院期間精神疾病患者死亡率高於非精神疾病患者。

精神疾病患者使用抗精神病藥物後得心肌梗塞風險高於非精神疾病個案。

懷孕婦女合併憂鬱症個案有較高比率的妊娠巨吐症(39.3% vs. 35.5%)、流產(3.3% vs. 2.6%) 與胎位不正(12.3% vs. 10.3%) 等妊娠併發症；對生產的影響為剖腹產的比例高(40.2% 34.6%)。

本組近年來協助各科別與醫師利用大數據進行研究，成效斐然，如：精神科-臧汝芬、林承儒、黃郁心、蘇煦涵、內分泌科-蔡明潔、小兒科-雷偉德、 直腸科-蔡柏立等醫師。

近2年來本組已執行6件院內外研究計畫，研究成果已發表15篇SCIE論文，其中四篇的研究成果並刊登在SCIE Psychology 或Psychiatry 領域排名前10%的相關期刊。

Chan YH, Kao YW, Cheng WH, Chen SW, Hung CL, Romiti GF, Lip GYH, Chao TF. Cardiovascular-kidney-metabolic interplay in patients with atrial fibrillation receiving direct oral anticoagulants. Europace. 2026 Mar 10;28(3):euag028. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 7.5, Ranking: 23/231=9.9%)

Ioannou A, Khouri MG, Kitai T, Vemulapalli S, Hung CL, Lim SC, Frost M, Tee WW, Mansell J, Sheikh A, Venneri L, Razvi Y, Porcari A, Martinez-Naharro A, Rauf MU, Lachmann H, Hawkins PN, Wechelakar A, Moody W, Bandera F, Ezekowitz JA, Lam CSP, Solomon SD, Gillmore JD, Fontana M. Diagnosis of cardiac amyloidosis on echocardiography using artificial intelligence. Circ Cardiovasc Imaging. 2026 Feb 12:e018991. (RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING) (IF: 7.0, Ranking: 11/213=5.2%)

Chen YJ, Liao PH, Hung CL, Chang WH, Shih SC. Impact of telehealth care on clinical outcomes in heart failure patients. J Telemed Telecare. 2026 Feb;32(2):101-111. (HEALTH CARE SCIENCES & SERVICES) (IF: 3.2, Ranking: 38/188=20.7%)

Chang YT, Chien CY, Huang WM, Hung CL, Zhang Q, Gonzales RA, Burrage MK, Piechnik SK, Ferreira VM, Yun CH. Differentiating ischemic from healthy myocardium using cardiovascular magnetic resonance dipyridamole rest and stress T1 mapping. Sci Rep. 2026 Feb 24;16(1):8926. (MULTIDISCIPLINARY SCIENCES) (IF: 3.9, Ranking: 25/136=18.4%)

Lien CW, Wang WJ, Lai KY, Yu JC, Lee CY, Wang J, Tsai MH, Hung CL, Sung SH, Kao HL, Ho YL, Takeuchi M, Yang LT. Profiles of comprehensive morphological phenotypes and outcomes in functional mitral regurgitation. JACC Asia. 2026 Apr;6(4):436-448.

Morris DA, Biering-Sørensen T, Skaarup K, Liao JN, Stawowy P, Trippel T, Hilgendorf I, Schneider-Reigbert M, Hung CL, Frydas A. Lower limit of the reference normal range for left atrial strain: a meta-analysis. JACC Cardiovasc Imaging. 2026 Jan 27:S1936-878X(25)00706-5. (RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING) (IF: 15.2, Ranking: 1/213=0.5%)

Hung CL, Chiang CE, Yeh HI. Management of HFpEF in Asian patients: evidence from major trials on HFpEF therapeutics. JACC Asia. 2025 Dec;5(12S):1-3.

Lin JL, Wu YW, Liao KM, Hung CL. NT-proBNP-based heart failure risk score for asymptomatic diabetic population in Asia: The DM-HEART Study. JACC Asia. 2025 Dec. (Accepted)

Chao TF, Lau CP, Choi EK, Ching CK, Chan NY, Hung CL, Joung B, Krittayaphong R, Tse HF, Lip GYH. Asia Pacific Heart Rhythm Society (APHRS) scientific statement on stroke prevention strategies in patients with device-detected atrial fibrillation: the 4S-DDAF approach. Lancet Reg Health West Pac. 2025 Dec 10;65:101770. (HEALTH CARE SCIENCES & SERVICES) (IF: 8.1, Ranking: 5/188=2.7%)

Chang PH, Liao FC, Wu YC, Sun FJ, Liu YY, Yeh HI, Hung CL, Wu KP. Machine learning enhanced acute heart failure phenotype prediction using natural language processing and random forest. Front Artif Intell. 2025 Oct 16;8:1664627. (COMPUTER SCIENCE, INFORMATION SYSTEMS) (IF: 4.7, Ranking: 56/258=21.7%)

Teng TK, Lam CSP; ASIAN-HF Executive Committee and Investigators. Comprehensive introduction to ASIAN-HF Registry. JACC Asia. 2025 Sep;5(9):1206-1216.

Hung CL, Liu YW, Wu YW. Mavacamten in symptomatic hypertrophic cardiomyopathy: a paradigm shift or revolution? JACC Asia. 2025 Aug;5(8):1075-1077.

Hsieh YW, Lee AS, Sung KT, Chen XR, Lai HH, Chen YF, Chien CY, Yeh HI, Chen CH, Hung CL. ALDH2 enzyme deficiency in diabetic cardiomyopathy. Int J Mol Sci. 2025 Jun 9;26(12):5516. (BIOCHEMISTRY & MOLECULAR BIOLOGY) (IF: 4.9, Ranking: 72/319=22.6%)

Lin YH, Tsai PS, Hung CL, Beg MF, Yeh HI, Yun CH, Wu MT. The role of muscle density in predicting the amputation risk in peripheral arterial disease: a tissue composition study using lower extremity CT angiography. Diagnostics (Basel). 2025 Jun 5;15(11):1439. (MEDICINE, GENERAL & INTERNAL) (IF: 3.3, Ranking: 57/332=17.2%)

Hung TC, Chien SC, Tsao CH, Wu YW, Yen CH, Hsiao CC, Lin HC, Tsai JP, Peng MC, Tsai CT, Hung CL. The association of coronary microvascular dysfunction and cardiac maladaptation with clinical outcomes in heart failure with preserved ejection fraction: A prospective dynamic SPECT study. Int J Cardiol. 2025 Apr 15;425:133064. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 3.2, Ranking: 68/231=29.4%)

Slater J, Maron DJ, Jones PG, Bangalore S, Reynolds HR, Fu Z, Stone GW, Kirby R, Hochman JS, Spertus JA; ISCHEMIA Research Group. Evaluating the appropriate use criteria for coronary revascularization in stable ischemic heart disease using randomized data from the ISCHEMIA trial. Circ Cardiovasc Qual Outcomes. 2025 Mar;18(3):e010849. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 6.7, Ranking: 28/231=12.1%)

Morris DA, Hung CL, Biering-Sørensen T, Kuznetsova T, Donal E, Kosmala W, Takeuchi M, Lang R, Tadic M, Ma CY, Belyavskiy E, Dreger H, Schneider-Reigbert M, Frydas A. Prognostic relevance and lower limit of the reference range of left ventricular global longitudinal strain: a clinical validation study. JACC Cardiovasc Imaging. 2025 May;18(5):525-536. (RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING) (IF: 7.0, Ranking: 1/213=0.5%)

Chen LY, Chen PL, Jiang ST, Lee HL, Liu YY, Chueh A, Lin JH, Chen CG, Hung CL, Hsu K. Increased anion exchanger-1 (band 3) on the red blood cell membrane accelerates scavenging of nitric oxide metabolites and predisposes hypertension risks. Function (Oxf). 2025 Feb 12;6(1):zqae052. (PHYSIOLOGY) (IF: 3.8, Ranking: 17/87=19.5%)

Chien SC, Lan WR, Yun CH, Sung KT, Yeh HI, Tsai CT, Chien CY, Hung CL. Functional and prognostic impacts of serum albumin with thoracic arterial calcification among asymptomatic individuals. Sci Rep. 2024 Oct 26;14(1):25477. (MULTIDISCIPLINARY SCIENCES) (IF: 3.9, Ranking: 25/136=18.4%)

Hsu HJ, Chang H, Lin CL, Yao WC, Hung CL, Pang SP, Kuo CF, Tsai SY. Increased risk of chronic fatigue syndrome following pneumonia: A population-based cohort study. J Infect Public Health. 2024 Aug;17(8):102495. (PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH) (IF: 4.0, Ranking: 57/421=13.5%)

Lee CY, Tsai CM, Chiang KC, Huang CC, Lin MS, Hung CL, Ho YL, Nkomo VT, Takeuchi M, Yang LT. Prognostic value of left ventricular and left atrial strain imaging in moderate to severe aortic stenosis: Insights from an Asian population. Int J Cardiol. 2024 Jul 15;407:132103. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 3.2, Ranking: 68/231=29.4%)

Tien TY, Wu YJ, Chang CY, Hung CL, Lee YN, Lee HI, Chou YH, Lin CF, Lee CW, Su CH, Yeh HI. Hsa-miR-134-5p predicts cardiovascular risk in circulating mononuclear cells and improves angiogenic action of senescent endothelial progenitor cells. J Cell Mol Med. 2024 Jul;28(13):e18523. (MEDICINE, RESEARCH & EXPERIMENTAL) (IF: 4.2, Ranking: 56/195=28.7%)

Liu YY, Tien TY, Hung CL, Wu YJ, Su CH, Yeh HI. Transdermal nicotine patch increases the number and function of endothelial progenitor cells in young healthy nonsmokers without adverse hemodynamic effects. Clin Pharmacol Ther. 2024 Jul;116(1):128-135. (PHARMACOLOGY & PHARMACY) (IF: 5.5, Ranking: 26/353=7.4%)

Hsu CY, Chung FP, Chao CJ, Chen YJ, Wu CK, Wu YW, Huang JL, Chu PH, Jia-Yin Hou C, Chang HY, Hung CL. Efficacy of sacubitril-valsartan on survival and cardiac remodeling in hypotensive heart failure with reduced ejection fraction: a multicenter study. Mayo Clin Proc. 2024 Jun;99(6):940-952. (MEDICINE, GENERAL & INTERNAL) (IF: 6.7, Ranking: 26/333=7.8%)

Hung CL, Yang NI, Chiang CE. Cardiovascular risk stratification by LV size among AF population: smaller is not always better. J Am Coll Cardiol. 2024 May 21;83(20):1970-1972. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 22.3, Ranking: 4/231=1.7%)

Sim DKL, Mittal S, Zhang J, Hung CL, Azman WAW, Choi JO, Yingchoncharoen T, De Lara ACF, Ito H, Ashraf T, Yiu KH, Krittayaphong R. Expert recommendations for the management of iron deficiency in patients with heart failure in Asia. Int J Cardiol. 2024 May 15;403:131890. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 3.2, Ranking: 68/231=29.4%)

Lin JL, Liu SC, Liu TF, Chuang SM, Huang CT, Chen YJ, Lee CC, Chien MN, Hou CJ, Yeh HI, Chiang CE, Hung CL. ELUCIDATE trial: a single-center randomized controlled study. J Am Heart Assoc. 2024 May 7;13(9):e033832. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 5.3, Ranking: 41/231=17.7%)

Chang HC, Chen YY, Kuo TT, Lin YJ, Chien KL, Chang HY, Hung CL, Chung FP. Sodium glucose transporter 2 inhibitors versus metformin on cardiovascular and renal outcomes in patients with diabetes with low cardiovascular risk: a nationwide cohort study. J Am Heart Assoc. 2024 Apr 16;13(8):e032397. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 5.3, Ranking: 41/231=17.7%)

Lin YH, Sung KT, Tsai CT, Lai YH, Lo CI, Yu FC, Lan WR, Hung TC, Kuo JY, Hou CJ, Yen CH, Peng MC, Yeh HI, Wu MT, Hung CL. Preclinical systolic dysfunction relating to ankle-brachial index among high-risk PAD population with preserved left ventricular ejection fraction. Sci Rep. 2024 Mar 14;14(1):6145. (MULTIDISCIPLINARY SCIENCES) (IF: 3.9, Ranking: 25/136=18.4%)

Lee AS, Hung CL, Lai TS, Chung CH. Investigation of the therapeutic potential of organic nitrates in mortality reduction following acute myocardial infarction in hyperlipidemia patients: a population-based cohort study. J Pers Med. 2024 Jan 22;14(1):124. (HEALTH CARE SCIENCES & SERVICES) (IF: 3.0, Ranking: 39/175=22.3%)

Myhre PL, Hung CL, Frost MJ, Jiang Z, Ouwerkerk W, Teramoto K, Svedlund S, Saraste A, Hage C, Tan RS, Beussink-Nelson L, Fermer ML, Gan LM, Hummel YM, Lund LH, Shah SJ, Lam CSP, Tromp J. External validation of a deep learning algorithm for automated echocardiographic strain measurements. Eur Heart J Digit Health. 2023 Nov 20;5(1):60-68. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 4.4, Ranking: 47/231=20.3%)

Cheng PN, Chen WJ, Hou CJ, Lin CL, Chang ML, Wang CC, Chang WT, Wang CY, Lin CY, Hung CL, Peng CY, Yu ML, Chao TH, Huang JF, Huang YH, Chen CY, Chiang CE, Lin HC, Li YH, Lin TH, Kao JH, Wang TD, Liu PY, Wu YW, Liu CJ. Taiwan Association for the Study of the Liver-Taiwan Society of Cardiology Taiwan position statement for the management of metabolic dysfunction- associated fatty liver disease and cardiovascular diseases. Clin Mol Hepatol. 2024 Jan;30(1):16-36. (GASTROENTEROLOGY & HEPATOLOGY) (IF: 16.9, Ranking: 6/148=4.0%)

Chung FP, Chao TF, Lee AS, Sung KT, Huang WH, Hsiao CC, Su CH, Yang LT, Chen YJ, Chen YY, Liao JN, Jia-Yin Hou C, Yeh HI, Hung CL. Discriminative ability of left ventricular strain in mildly reduced ejection fraction heart failure. JACC Adv. 2023 Nov 24;2(9):100654.

Chang H, Kuo CF, Yu TS, Ke LY, Hung CL, Tsai SY. Increased risk of chronic fatigue syndrome following infection: a 17-year population-based cohort study. J Transl Med. 2023 Nov 11;21(1):804. (MEDICINE, RESEARCH & EXPERIMENTAL) (IF: 7.5, Ranking: 24/195=12.3%)

Sung KT, Chang HY, Hsu NW, Huang WH, Lin YH, Yun CH, Hsiao CC, Hsu CY, Tsai SY, Chen YJ, Tsai CT, Su CH, Hung TC, Hou CJ, Yeh HI, Hung CL. Penalized model-based unsupervised phenomapping unravels distinctive HFrEF phenotypes with improved outcomes discrimination from Sacubitril/Valsartan treatment independent of MAGGIC score. J Am Heart Assoc. 2023 Sep 19;12(18):e028860. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 5.3, Ranking: 41/231=17.7%)

Wu CK, Yang LT, Hung CL. Exercise left atrial compliance: One more tool in the heart failure with preserved ejection fraction assistance toolbox? Eur J Heart Fail. 2023 Aug;25(8):1307-1309. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 10.8, Ranking: 12/231=5.2%)

Teramoto K, Ouwerkerk W, Tay WT, Tromp J, Katherine Teng TH, Chandramouli C, Fermer ML, Hung CL, Anand I, Solomon SD, Voors AA, McMurray JJV, Lund LH, Shah SJ, Richards AM, Lam CSP; ASIAN-HF Investigators. Clinical features of heart failure with normal ejection fraction: insights from the ASIAN-HF Registry. JACC Asia. 2023 Aug 22;3(5):739-751.

Lee AS, Sung YL, Pan SH, Sung KT, Su CH, Ding SL, Lu YJ, Hsieh CL, Chen YF, Liu CC, Chen WY, Chen XR, Chung FP, Wang SW, Chen CH, Mochly-Rosen D, Hung CL, Yeh HI, Lin SF. A common East Asian aldehyde dehydrogenase 2*2 variant promotes ventricular arrhythmia with chronic light-to-moderate alcohol use in mice. Commun Biol. 2023 Jun 6;6(1):610. (BIOLOGY) (IF: 5.1, Ranking: 8/107=7.5%)

Lawson CA, Tay WT, Richards M, Zaccardi F, Tromp J, Teng TK, Hung CL, Chandramouli C, Wander GS, Ouwerkerk W, Teramoto K, Ali M, Kadam U, Hand S, Harrison M, Anand I, Naik A, Squire I, Khunti K, Stromberg A, Lam CSP; ASIAN-HF Investigators. Patient-Reported Status and Heart Failure Outcomes in Asia by Sex, Ethnicity, and Socioeconomic Status. JACC Asia. 2023 Jun 6;3(3):349-362.

Wang TD, Hung CL, Yeh HI. Predicted but not destined: considerations for obesity-related cardiovascular risk projection. Lancet Reg Health West Pac. 2023 Jun 19;37:100828. (HEALTH CARE SCIENCES & SERVICES) (IF: 8.1, Ranking: 5/188=2.7%)

Lawson CA, Tay WT, Bernhardt L, Richards AM, Zaccardi F, Tromp J, Katherine Teng TH, Hung CL, Chandramouli C, Wander GS, Ouwerkerk W, Seidu S, Khunti K, Lam CSP; ASIAN-HF Investigators. Association between diabetes, chronic kidney disease, and outcomes in people with heart failure from Asia. JACC Asia. 2023 May 2;3(4):611-621.

Wu PC, Sung KT, Lin JL, Hung TC, Lai YH, Su CH, Yeh HI, Wu CJ, Hung CL. Relation of early-stage renal insufficiency and cardiac structure and function in a large population of asymptomatic Asians: a cross-sectional cohort analysis. Front Nephrol. 2023 May 12;3:1071900.

Valsaraj A, Kalmady SV, Sharma V, Frost M, Sun W, Sepehrvand N, Ong M, Equilbec C, Dyck JRB, Anderson T, Becher H, Weeks S, Tromp J, Hung CL, Ezekowitz JA, Kaul P. Development and validation of echocardiography-based machine-learning models to predict mortality. EBioMedicine. 2023 Apr;90:104479. (MEDICINE, RESEARCH & EXPERIMENTAL) (IF: 10.8, Ranking: 13/195=6.7%)

Lin CY, Sung HY, Chen YJ, Yeh HI, Hou CJ, Tsai CT, Hung CL. Personalized management for heart failure with preserved ejection fraction. J Pers Med. 2023 Apr 27;13(5):746. (HEALTH CARE SCIENCES & SERVICES) (IF: 3.0, Ranking: 39/175=22.3%) 

Sung KT, Chang SH, Chi PC, Chien SC, Lo CI, Lin CF, Huang WH, Yun CH, Tsai CT, Su CH, Hou CJ, Yeh HI, Tsao CH, Kuo JY, Hung CL. QRS fragmentation in preserved ejection fraction heart failure: functional insights, pathological correlates, and prognosis. J Am Heart Assoc. 2023 Mar 21;12(6):e028105. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 5.3, Ranking: 41/231=17.7%)

Yang LT, Lee CC, Su CH, Amano M, Nabeshima Y, Kitano T, Tsai CM, Hung CL, Nakaoku Y, Nishimura K, Ogata S, Lo HY, Hsu RB, Chen YS, Chen WJ, Mankad R, Pellikka PA, Ho YL, Takeuchi M, Izumi C. Analysis of left ventricular indexes and mortality among Asian adults with hemodynamically significant chronic aortic regurgitation. JAMA Netw Open. 2023 Mar 1;6(3):e234632. (MEDICINE, GENERAL & INTERNAL) (IF: 9.7, Ranking: 16/332=4.8%)

Lee YN, Wu YJ, Lee HI, Wang HH, Hung CL, Chang CY, Chou YH, Tien TY, Lee CW, Lin CF, Su CH, Yeh HI. Hsa-miR-409-3p regulates endothelial progenitor senescence via PP2A-P38 and is a potential ageing marker in humans. J Cell Mol Med. 2023 Mar;27(5):687-700. (MEDICINE, RESEARCH & EXPERIMENTAL) (IF: 4.2, Ranking: 56/195=28.7%)

Chen C, Yip HT, Leong KH, Yao WC, Hung CL, Su CH, Kuo CF, Tsai SY. Presence of depression and anxiety with distinct patterns of pharmacological treatments before the diagnosis of chronic fatigue syndrome: a population-based study in Taiwan. J Transl Med. 2023 Feb 8;21(1):98. (MEDICINE, RESEARCH & EXPERIMENTAL) (IF: 7.5, Ranking: 24/195=12.3%)

Teramoto K, Tay WT, Tromp J, Katherine Teng TH, Chandramouli C, Ouwerkerk W, Lawson CA, Huang W, Hung CL, Chopra V, Anand I, Mark Richards A, Lam CSP. Patient-reported versus physician-assessed health status in heart failure with reduced and preserved ejection fraction from ASIAN-HF Registry. Circ Cardiovasc Qual Outcomes. 2023 Jan;16(1):e009134. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 6.7, Ranking: 28/231=12.1%)

Hung CL, Chao TF, Tsai CT, Liao JN, Lim SS, Tuan TC, Chen TJ, Chan YH, Chen SA, Chiang CE. Prevalence, incidence, lifetime risks, and outcomes of heart failure in Asia: a nationwide report. JACC Heart Fail. 2023 Oct;11(10):1454-1456. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 11.8, Ranking: 9/231=3.9%)

Niu CY, Yang SF, Ou SM, Wu CH, Huang PH, Hung CL, Lin CC, Li SY. Sacubitril/Valsartan in patients with heart failure and concomitant end-stage kidney disease. J Am Heart Assoc. 2022 Sep 20;11(18):e026407. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 5.3, Ranking: 41/231=17.7%)

Chang HC, Kuo TT, Chen YY, Lin YJ, Chang HY, Hung CL, Chung FP. Sodium-glucose cotransporter 2 inhibitors in cardiovascular and renal outcomes in patients with diabetes but without established cardiovascular disease: a nationwide population-based cohort study. Diabetes Care. 2022 Sep 1;45(9):129-130. (ENDOCRINOLOGY & METABOLISM) (IF: 16.6, Ranking: 5/193=2.6%)

Jin X, Nauta JF, Hung CL, Ouwerkerk W, Teng TK, Voors AA, Lam CS, van Melle JP. Left atrial structure and function in heart failure with reduced (HFrEF) versus preserved ejection fraction (HFpEF): systematic review and meta-analysis. Heart Fail Rev. 2022 Sep;27(5):1933-1955. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 4.2, Ranking: 50/231=21.6%)

Hu CY, Hung CL, Huang YC, Huang PH, Tseng DY, Lin YH, Sun FJ, Kao FJ, Yeh HI, Liu YY. Alcohol patch test with hue-saturation-value model analysis predicts ALDH2 genetic polymorphism. Comput Biol Med. 2022 Aug;147:105783. (BIOLOGY) (IF: 6.3, Ranking: 7/107=6.5%)

Lee CW, Yun CH, Huang WH, Hung TC, Tsai CT, Kuo JY, Su CH, Cheng HE, Hung CL, Hou CJ. The association of pericardial fat and peri-aortic fat with severity of nonalcoholic fatty liver disease. Sci Rep. 2022 Aug 18;12(1):14014. (MULTIDISCIPLINARY SCIENCES) (IF: 3.9, Ranking: 25/136=18.4%)

Jin X, Hung CL, Tay WT, Soon D, Sim D, Sung KT, Loh SY, Lee S, Jaufeerally F, Ling LH, Richards AM, van Melle JP, Voors AA, Lam CSP. Epicardial adipose tissue related to left atrial and ventricular function in heart failure with preserved versus reduced and mildly reduced ejection fraction. Eur J Heart Fail. 2022 Aug;24(8):1346-1356. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 10.8, Ranking: 12/231=5.2%)

Wu CK, Yang NI, Hung CL. Right or left heart failure: partners in crime. JACC Asia. 2022 May 17;2(3):244-246.

Hung PF, Chung FP, Hung CL, Lin YJ, Kuo TT, Liao JN, Chen YY, Pan CH, Shaw KP, Chen SA. Decreased expression of plakophilin-2 and αt-catenin in arrhythmogenic right ventricular cardiomyopathy: potential markers for diagnosis. Int J Mol Sci. 2022 May 16;23(10):5529. (BIOCHEMISTRY & MOLECULAR BIOLOGY) (IF: 4.9, Ranking: 72/319=22.6%)

Huang WM, Wu WJ, Yang SH, Sung KT, Hung TC, Hung CL, Yun CH. Quantitative volumetric computed tomography embolic analysis, the Qanadli score, biomarkers, and clinical prognosis in patients with acute pulmonary embolism. Sci Rep. 2022 May 10;12(1):7620. (MULTIDISCIPLINARY SCIENCES) (IF: 3.9, Ranking: 25/136=18.4%)

Lai YH, Su CH, Hung TC, Yun CH, Tsai CT, Yeh HI, Hung CL. Association of non-alcoholic fatty liver disease and hepatic fibrosis with epicardial adipose tissue volume and atrial deformation mechanics in a large Asian population free from clinical heart failure. Diagnostics (Basel). 2022 Apr 6;12(4):916. (MEDICINE, GENERAL & INTERNAL) (IF: 3.3, Ranking: 57/332=17.2%)

Hsu NW, Chou KC, Wang YT, Hung CL, Kuo CF, Tsai SY. Building a model for predicting metabolic syndrome using artificial intelligence based on an investigation of whole-genome sequencing. J Transl Med. 2022 Apr 28;20(1):190. (MEDICINE, RESEARCH & EXPERIMENTAL) (IF: 7.5, Ranking: 24/195=12.3%)

Sundaram V, Nagai T, Chiang CE, Reddy YNV, Chao TF, Zakeri R, Bloom C, Nakai M, Nishimura K, Hung CL, Miyamoto Y, Yasuda S, Banerjee A, Anzai T, Simon DI, Rajagopalan S, Cleland JGF, Sahadevan J, Quint JK. Hospitalization for heart failure in the United States, UK, Taiwan, and Japan: An international comparison of administrative health records on 413,385 individual patients. J Card Fail. 2022 Mar;28(3):353-366. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 8.2, Ranking: 19/231=8.2%)

So A, Yang Z, Li L, Li W, Pan C, Vivekanantha P, Yun HW, Xie XY, Yun CH, Huang WM, Hung CL, Gao M, Zhang X, Zha Y, Shen J. Relationship between lung injury extent and phenotype manifested in non-contrast CT and cardiac injury during acute stage of COVID-19. Int J Cardiol Heart Vasc. 2022 Feb;38:100938. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 3.2, Ranking: 68/231=29.4%)

Hsuan CF, Lin FJ, Lee TL, Yang KC, Tseng WK, Wu YW, Yin WH, Yeh HI, Chen JW, Wu CC; Taiwanese Secondary Prevention for Patients with AtheRosCLErotic Disease (T-SPARCLE) Registry Investigators. The waist-to-body mass index ratio as an anthropometric predictor for cardiovascular outcome in subjects with established atherosclerotic cardiovascular disease. Sci Rep. 2022 Jan 17;12(1):804. (MULTIDISCIPLINARY SCIENCES) (IF: 3.9, Ranking: 25/136=18.4%)

Tromp J, Seekings PJ, Hung CL, Iversen MB, Frost MJ, Ouwerkerk W, Jiang Z, Eisenhaber F, Goh RSM, Zhao H, Huang W, Ling LH, Sim D, Cozzone P, Richards AM, Lee HK, Solomon SD, Lam CSP, Ezekowitz JA. Automated interpretation of systolic and diastolic function on the echocardiogram: a multicohort study. Lancet Digit Health. 2022 Jan;4(1):e46-e54. (MEDICAL INFORMATICS) (IF: 24.1, Ranking: 1/48=2.1%)

Sung KT, Kuo JY, Yun CH, Lin YH, Tsai JP, Lo CI, Hsiao CC, Lai YH, Tsai CT, Hou CJ, Su CH, Yeh HI, Chien CY, Hung TC, Hung CL. Association of region-specific cardiac adiposity with dysglycemia and new-onset diabetes. J Am Heart Assoc. 2021 Dec 21;10(24):e021921. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 5.3, Ranking: 41/231=17.7%)

Yun CH, Hung CL, Wen MS, Wan YL, So A. CT assessment of myocardial perfusion and fractional flow reserve in coronary artery disease: a review of current clinical evidence and recent developments. Korean J Radiol. 2021 Nov;22(11):1749-1763. (RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING) (IF: 5.3, Ranking: 22/213=10.3%)

Chien SC, Hsu CY, Liu HY, Lin CF, Hung CL, Huang CY, Chien LN. Cardiogenic shock in Taiwan from 2003 to 2017 (CSiT-15 study). Crit Care. 2021 Nov 18;25(1):402. (CRITICAL CARE MEDICINE) (IF: 9.3, Ranking: 4/62=6.5%)

Tay WT, Teng TK, Simon O, Ouwerkerk W, Tromp J, Doughty RN, Richards AM, Hung CL, Qin Y, Aung T, Anand I, Lam CSP; ASIAN‐HF Investigators. Readmissions, death and its associated predictors in heart failure with preserved versus reduced ejection fraction. J Am Heart Assoc. 2021 Nov 16;10(22):e021414. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 5.3, Ranking: 41/231=17.7%)

Huang WH, Sung KT, Kuo JY, Chen YJ, Huang CT, Chien SC, Tsai JP, Lo CI, Hsiao CC, Lin JL, Tsai IH, Yun CH, Su CH, Hung TC, Yeh HI, Hung CL. Atrioventricular longitudinal mechanics using novel speckle-tracking improved risk stratification beyond baseline thyroid hormone in asymptomatic subclinical hypothyroidism. Circ Cardiovasc Imaging. 2021 Nov;14(11):e012433. (RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING) (IF: 7.0, Ranking: 11/213=5.2%)

Chiou YA, Hung CL, Lin SF. AI-assisted echocardiographic prescreening of heart failure with preserved ejection fraction on the basis of intrabeat dynamics. JACC Cardiovasc Imaging. 2021 Nov;14(11):2091-2104. (RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING) (IF: 15.2, Ranking: 1/213=0.5%) 

Hung CL, Sung KT, Chang SC, Liu YY, Kuo JY, Huang WH, Su CH, Liu CC, Tsai SY, Liu CY, Lee AS, Pan SH, Wang SW, Hou CJ, Hung TC, Yeh HI. Variant Aldehyde Dehydrogenase 2 (ALDH2*2) as a risk factor for mechanical LA substrate formation and atrial fibrillation with modest alcohol consumption in Ethnic Asians. Biomolecules. 2021 Oct 21;11(11):1559. (BIOCHEMISTRY & MOLECULAR BIOLOGY) (IF: 4.8, Ranking: 75/320=23.4%)

Tsou MT, Chang YC, Hsu CP, Kuo YC, Yun CH, Huang WH, Hu KC, Liu CY, Chen YJ, Sung KT, Liu CC, Hung CL, Kuo JY, Chen TY, Hung TC, Yeh HI. Visceral adiposity index outperforms conventional anthropometric assessments as predictor of diabetes mellitus in elderly Chinese: a population-based study. Nutr Metab (Lond). 2021 Sep 25;18(1):87. (NUTRITION & DIETETICS) (IF: 4.1, Ranking: 29/113=25.7%)

Chien SC, Chandramouli C, Lo CI, Lin CF, Sung KT, Huang WH, Lai YH, Yun CH, Huang C, Yeh HI, Hung TC, Hung CL, Lam CSP. Correction: Associations of obesity and malnutrition with cardiac remodeling and cardiovascular outcomes in Asian adults: A cohort study. PLoS Med. 2021 Sep 13;18(9):e1003784. (MEDICINE, GENERAL & INTERNAL) (IF: 9.9, Ranking: 12/333=3.6%)

Yen CH, Lin JL, Sung KT, Su CH, Huang WH, Chen YY, Chien SC, Lai YH, Lee PY, Liu YY, Tsai JP, Tsai CT, Hou CJ, Chen YJ, Hsieh YJ, Hung CL, Hung TC, Yeh HI. Association of free fatty acid binding protein with central aortic stiffness, myocardial dysfunction and preserved ejection fraction heart failure. Sci Rep. 2021 Aug 13;11(1):16501. (MULTIDISCIPLINARY SCIENCES) (IF: 3.9, Ranking: 25/136=18.4%)

Kipke J, Margevicius S, Kityo C, Mirembe G, Buggey J, Yun CH, Hung CL, McComsey GA, Longenecker CT. Sex, HIV status, and measures of cardiac stress and fibrosis in Uganda. J Am Heart Assoc. 2021 Jun;10(11):e018767. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 5.3, Ranking: 41/231=17.7%)

Chien SC, Chandramouli C, Lo CI, Lin CF, Sung KT, Huang WH, Lai YH, Yun CH, Su CH, Yeh HI, Hung TC, Hung CL, Lam CSP. Associations of obesity and malnutrition with cardiac remodeling and cardiovascular outcomes in Asian adults: A cohort study. PLoS Med. 2021 Jun 1;18(6):e1003661. (MEDICINE, GENERAL & INTERNAL) (IF: 9.9, Ranking: 12/333=3.6%)

Jan YT, Tsai PS, Longenecker CT, Lin DC, Yun CH, Sung KT, Liu CC, Kuo JY, Hung CL, Wu TH, Lin JL, Hou CJ, Tsai CT, Chien CY, So A. Thoracic aortic calcification and pre-clinical hypertension by new 2017 ACC/AHA hypertension guidelines. Diagnostics (Basel). 2021 Jun 3;11(6):1027. (MEDICINE, GENERAL & INTERNAL) (IF: 3.3, Ranking: 57/332=17.2%)

Han CL, Chen XR, Lan A, Hsu YL, Wu PS, Hung PF, Hung CL, Pan SH. N-glycosylated GPNMB ligand independently activates mutated EGFR signaling and promotes metastasis in NSCLC. Cancer Sci. 2021 May;112(5):1911-1923. (ONCOLOGY) (IF: 4.3, Ranking: 88/328=26.8%)

Liao JN, Chao TF, Hung CL, Chen SA. The decrease in peak atrial longitudinal strain in patients with atrial fibrillation as a practical parameter for stroke risk stratification. Heart Rhythm. 2021 Apr;18(4):538-544. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 5.8, Ranking: 32/231=13.9%)

Teng TK, Tay WT, Richards AM, Chew TSM, Anand I, Ouwerkerk W, Chandramouli C, Huang W, Lawson CA, Kadam UT, Yap J, Lim S, Hung CL, MacDonald MR, Loh SY, Shimizu W, Tromp J, Lam CSP; ASIAN-HF investigators‡. Socioeconomic status and outcomes in heart failure with reduced ejection fraction from Asia. Circ Cardiovasc Qual Outcomes. 2021 Apr;14(4):e006962. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 6.7, Ranking: 28/231=12.1%) 

Hung CL, Chao TF, Su CH, Liao JN, Sung KT, Yeh HI, Chiang CE. Income level and outcomes in patients with heart failure with universal health coverage. Heart. 2021 Feb;107(3):208-216. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 4.4, Ranking: 47/231=20.3%)

Lin HY, Chen MR, Lee CL, Lin SM, Hung CL, Niu DM, Chang TM, Chuang CK, Lin SP. Natural progression of cardiac features and long-term effects of enzyme replacement therapy in Taiwanese patients with mucopolysaccharidosis II. Orphanet J Rare Dis. 2021 Feb 23;16(1):99. (GENETICS & HEREDITY) (IF: 3.5, Ranking: 61/192=31.8%)

Lin JL, Sung KT, Lai YH, Yen CH, Yun CH, Su CH, Kuo JY, Liu CY, Chien CY, Cury RC, Bezerra HG, Hung CL. Epicardial adiposity in relation to metabolic abnormality, circulating adipocyte FABP, and preserved ejection fraction heart failure. Diagnostics (Basel). 2021 Feb 26;11(3):397. (MEDICINE, GENERAL & INTERNAL) (IF: 3.3, Ranking: 57/332=17.2%)

Huang KC, Huang CS, Su MY, Hung CL, Ethan Tu YC, Lin LC, Hwang JJ. Artificial intelligence aids cardiac image quality assessment for improving precision in strain measurements. JACC Cardiovasc Imaging. 2021 Feb;14(2):335-345. (RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING) (IF: 15.2, Ranking: 1/213=0.5%)

Lai YH, Liu LY, Sung KT, Tsai JP, Huang WH, Yun CH, Lin JL, Chen YJ, Su CH, Hung TC, Hung CL, Kuo JY. Diverse adiposity and atrio-ventricular dysfunction across obesity phenotypes: implication of epicardial fat analysis. Diagnostics (Basel). 2021 Feb 27;11(3):408. (MEDICINE, GENERAL & INTERNAL) (IF: 3.3, Ranking: 57/332=17.2%)

Lin HY, Chen MR, Lee CL, Lin SM, Hung CL, Niu DM, Chang TM, Chuang CK, Lin SP. Aortic root dilatation in Taiwanese patients with mucopolysaccharidoses and the long-term effects of enzyme replacement therapy. Diagnostics (Basel). 2020 Dec 23;11(1):16. (MEDICINE, GENERAL & INTERNAL) (IF: 3.3, Ranking: 57/332=17.2%)

Tsou MT, Yun CH, Lin JL, Sung KT, Tsai JP, Huang WH, Liu CY, Hou CJ, Tsai IH, Su CH, Hung CL, Hung TC. Visceral adiposity, pro-inflammatory signaling and vasculopathy in metabolically unhealthy non-obesity phenotype. Diagnostics (Basel). 2020 Dec 29;11(1):40. (MEDICINE, GENERAL & INTERNAL) (IF: 3.3, Ranking: 57/332=17.2%)

Huang BH, Chang SC, Yun CH, Sung KT, Lai YH, Lo CI, Huang WH, Chien SC, Liu LY, Hung TC, Kuo JY, Lin JL, Bulwer B, Hou CJ, Chen YJ, Su CH, Yeh HI, Hung CL. Associations of region-specific visceral adiposity with subclinical atrial dysfunction and outcomes of heart failure. ESC Heart Fail. 2020 Dec;7(6):3545-3560. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 3.7, Ranking: 55/231=23.8%)

Kuo JY, Chang SH, Sung KT, Chi PC, Liao JN, Chao TF, Su CH, Yeh HI, Hung CL. Left ventricular dysfunction in atrial fibrillation and heart failure risk. ESC Heart Fail. 2020 Dec;7(6):3694-3706. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 3.7, Ranking: 55/231=23.8%)

Liu LY, Yun CH, Kuo JY, Lai YH, Sung KT, Yuan PJ, Tsai JP, Huang WH, Lin YH, Hung TC, Chen YJ, Su CH, Tsai CT, Yeh HI, Hung CL. Aortic root remodeling as an indicator for diastolic dysfunction and normative ranges in Asians: comparison and validation with multidetector computed tomography. Diagnostics (Basel). 2020 Sep 18;10(9):712. (MEDICINE, GENERAL & INTERNAL) (IF: 3.3, Ranking: 57/332=17.2%)

Tan ESJ, Goh V, Santema BT, Tay WT, Teng TK, Yap J, Tromp J, Hung CL, Chopra V, Anand I, MacDonald MR, Ling LH; ASIAN-HF investigators; Van Gelder IC, Rienstra M, Voors AA, Richards AM, Lam CSP. Ethnic differences in atrial fibrillation among patients with heart failure in Asia. ESC Heart Fail. 2020 Aug;7(4):1419-1429. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 3.7, Ranking: 55/231=23.8%)

Liao JN, Chao TF, Kuo JY, Sung KT, Tsai JP, Lo CI, Lai YH, Su CH, Hung CL, Yeh HI. Global left atrial longitudinal strain using 3-beat method improves risk prediction of stroke over conventional echocardiography in atrial fibrillation. Circ Cardiovasc Imaging. 2020 Aug;13(8):e010287. (RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING) (IF: 7.0, Ranking: 11/213=5.2%)

Zhou KN, Sung KT, Yen CH, Su CH, Lee PY, Hung TC, Huang WH, Chien SC, Tsai JP, Yun CH, Chang SC, Yeh HI, Hung CL. Carotid arterial mechanics as useful biomarker of extracellular matrix turnover and preserved ejection fraction heart failure. ESC Heart Fail. 2020 Aug;7(4):1615-1625. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 3.7, Ranking: 55/231=23.8%)

Ouwerkerk W, Teng TK, Tromp J, Tay WT, Cleland JG, van Veldhuisen DJ, Dickstein K, Ng LL, Lang CC, Anker SD, Zannad F, Hung CL, Sawhney JPS, Naik A, Shimizu W, Hagiwara N, Wander GS, Anand I, Richards AM, Voors AA, Lam CSP. Effects of combined renin-angiotensin-aldosterone system inhibitor and beta-blocker treatment on outcomes in heart failure with reduced ejection fraction: insights from BIOSTAT-CHF and ASIAN-HF registries. Eur J Heart Fail. 2020 Aug;22(8):1472-1482. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 10.8, Ranking: 12/231=5.2%)

Wang KT, Liu YY, Sung KT, Liu CC, Su CH, Hung TC, Hung CL, Chien CY, Yeh HI. Circulating monocyte count as a surrogate marker for ventricular-arterial remodeling and incident heart failure with preserved ejection fraction. Diagnostics (Basel). 2020 May 8;10(5):287. (MEDICINE, GENERAL & INTERNAL) (IF: 3.3, Ranking: 57/332=17.2%)

Lin HY, Chuang CK, Lee CL, Chen MR, Sung KT, Lin SM, Hou CJ, Niu DM, Chang TM, Hung CL, Lin SP. Cardiac evaluation using two-dimensional speckle-tracking echocardiography and conventional echocardiography in Taiwanese patients with mucopolysaccharidoses. Diagnostics (Basel). 2020 Jan 23;10(2):62. (MEDICINE, GENERAL & INTERNAL) (IF: 3.3, Ranking: 57/332=17.2%)

Buggey J, Yun L, Hung CL, Kityo C, Mirembe G, Erem G, Truong T, Ssinabulya I, Tang WHW, Hoit BD, McComsey GA, Longenecker CT. HIV and pericardial fat are associated with abnormal cardiac structure and function among Ugandans. Heart. 2020 Jan;106(2):147-153. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 4.4, Ranking: 47/231=20.3%)

MacDonald MR, Tay WT, Teng TK, Anand I, Ling LH, Yap J, Tromp J, Wander GS, Naik A, Ngarmukos T, Siswanto BB, Hung CL, Richards AM, Lam CSP; ASIAN‐F investigators †; ASIAN‐F investigators. Regional variation of mortality in heart failure with reduced and preserved ejection fraction across Asia: Outcomes in the ASIAN-HF Registry. J Am Heart Assoc. 2020 Jan 7;9(1):e012199. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 5.3, Ranking: 41/231=17.7%)