免疫基因研究組

研究員：許淳欣 研究員

顧問：朱正中 博士

研究人員 ：李慧玲、胡恬、林敬恆、黃家盉

進駐研究醫師：

小兒神經科 -
   邱南昌、何啟生、李松澤、陳慧如、林宜潔、
   柯信如、 黃佳雲、林佳柔、張家綺、游雅嵐

骨科 - 陳暐錚
血液腫瘤科 - 陳功深

合作單位： 

台東馬偕心臟內科-王光德、趙川磊；
臺北市立大學運動學院：曾國維、曾暐晉、陳永盛

研究米田堡血型表現在循環、呼吸生理及代謝上的角色。

研發自體抗體檢驗方法及改良；研究自體免疫腦炎之致病機轉。

與HLA相關疾病之研究；血小板、及顆粒球之自體抗體之研究。

A simple determination of Miltenberger blood group antigen Mi.III by PCR. (Taiwan Invention Patent No. I437229；effective from 2014/05/11 to 2031/11/10) 。

基因修飾小鼠、用以製備該基因修飾小鼠之方法及其用途 (Taiwan Invention Patent中華明國專利證書發明I883824號；專利權期限 05/11/2025 – 02/16/2044 ) 。

自體免疫腦炎檢驗方法建立及改良。

HLA高解析核酸序列、血小板特異抗原(HPA)、及顆粒球特異抗原(HNA)之分型、及抗體鑑定。

已開發出”米田堡血型基因敲入鼠” (已獲得中華民國專利)。

米田堡血型蛋白相關的生化與生理之研究。

利用專利之PCR分型技術，已完成東南亞族群GP.Mur (MiIII) 頻率分佈之研究。

已建立以DNA為基礎的血小板及嗜中性白血球抗原系統之分型技術、及異體抗體偵測的技術。

已完成HLA-A、B、C、DRB1、DQB1及DPB1等基因座的核酸定序分型法(Sequence-based typing, SBT)之建立及血小板抗原系統(HPA-1,2,3,4,5,15)在台灣族群中抗原分佈情形。

Chen LY, Chen PL, Jiang ST, Lee HL, Liu YY, Chueh A, Lin JH, Chen CG, Hung CL, Hsu K. Increased anion exchanger-1 (band 3) on the red blood cell membrane accelerates scavenging of nitric oxide metabolites and predisposes hypertension risks. Function (Oxf). 2025 Feb 12;6(1):zqae052. (PHYSIOLOGY) (IF: 3.8, Ranking: 17/87=19%) [APSselect (collection from the American Physiological Society)]

Wang C, Su NW, Hsu K, Kao CW, Chang MC, Chang YF, Lim KH, Chiang YH, Chang YC, Sung MT, Wu HH, Chen CG. The implication of serum HLA-G in angiogenesis of multiple myeloma. Mol Med. 2024 Jun 14;30(1):86. (BIOCHEMISTRY & MOLECULAR BIOLOGY) (IF: 6.0, Ranking: 50/313=16.0%)

Hsu K. Erythroid anion transport, nitric oxide, and blood pressure. Front Physiol. 2024 Apr 10;15:1363987. (PHYSIOLOGY) (IF: 3.2, Ranking: 24/85=28.24%) Su NW, Dai SH, Hsu K, Chang KM, Ko CC, Kao CW, Chang YF, Chen CG. PD-L1-positive circulating endothelial progenitor cells associated with immune response to PD-1 blockade in patients with head and neck squamous cell carcinoma. Cancer Immunol Immunother. 2024 Jan 4;73(1):3. (ONCOLOGY) (IF: 4.6, Ranking: 76/322=23.6%)

Chen PL, Huang KT, Chen LY, Hsu K. Erythroid anion Exchanger-1 (band 3) transports nitrite for nitric oxide metabolism. Free Radic Biol Med. 2024 Jan;210:237-245. (ENDOCRINOLOGY & METABOLISM) (IF: 7.1, Ranking: 15/186=8.1%)

Hsu K, Tseng WC, Chen LY, Chen PL, Lu YX, Chen YS, Tseng KW, Swenson ER. Effects of greater erythroid Cl-/HCO3- transporter (band 3) expression on ventilation and gas exchange during exhaustive exercise. Am J Physiol Lung Cell Mol Physiol. 2023 Jun 1;324(6):L825-L835. (PHYSIOLOGY) (IF: 3.6, Ranking: 19/85=22.4%) [Journal spotlight cover]

Hsu K. Differential enzymatic deglycosylation reveals attachment of red cell B antigen onto the carbohydrate moiety of glycophorin A and glycophorin B. Vox Sang. 2023 Feb;118(2):147-152. (HEMATOLOGY) (IF: 1.8, Ranking: 66/97=68.0%)

Hsu K, Lee TY, Lin JY, Chen PL. A Balance between Transmembrane-Mediated ER/Golgi Retention and Forward Trafficking Signals in Glycophorin-Anion Exchanger-1 Interaction. Cells. 2022 Nov 6;11(21):3512. (CELL BIOLOGY) (IF:5.1, Ranking: 63/205=30.7%)

Chen YC, Hsu KN, Lai JC, Chen LY, Kuo MS, Liao CC, Hsu K. Influence of hemoglobin on blood pressure among people with GP.Mur blood type☆. J Formos Med Assoc. 2022 Sep;121(9):1721-1727. (MEDICINE, GENERAL & INTERNAL) (IF:2.6, Ranking: 70/325=21.5%) [Media coverage by the International Society of Blood Transfusion (ISBT)]

Kuo MS, Chuang CH, Cheng HC, Lin HR, Wang JS, Hsu K. Different involvement of band 3 in red cell deformability and osmotic fragility-a comparative GP.Mur erythrocyte study. Cells. 2021 Nov 30;10(12):3369. (CELL BIOLOGY) (IF:5.1, Ranking: 63/205=30.7%)

Hsu K, Liu YY, Tseng WC, Huang KT, Liu CY, Chen LY, Lee HL, Lin HJ, Tseng KW, Yeh HI. Comodulation of NO-dependent vasodilation by erythroid band 3 and hemoglobin: A GP.Mur athlete study. Front Cardiovasc Med. 2021 Nov 29;8:740100. (CARDIAC & CARDIOVASCULAR SYSTEMS) (IF:2.8, Ranking: 79/220=35.9%)